Past history of anorexia nervosa in women with obsessive-compulsive disorder

1986 ◽  
Vol 5 (6) ◽  
pp. 1069-1075 ◽  
Author(s):  
Y. G. Kasvikis ◽  
F. Tsakiris ◽  
I. M. Marks ◽  
M. Basoglu ◽  
H. F. Noshirvani
Keyword(s):  
Anorexia Nervosa ◽  
Obsessive Compulsive Disorder ◽  
Past History ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
History Of

Gender Differences in Obsessive Compulsive Disorder

1995 ◽  
Vol 29 (1) ◽  
pp. 114-117 ◽  
Author(s):  
David J. Castle ◽  
Alicia Deale ◽  
Isaac M. Marks
Keyword(s):  
Gender Differences ◽  
Eating Disorder ◽  
Anxiety Disorders ◽  
Obsessive Compulsive Disorder ◽  
Past History ◽  
Onset Age ◽  
Obsessive Compulsive ◽  
Behavioural Treatment ◽  
Compulsive Disorder ◽  
History Of

We investigated gender differences in 219 patients with obsessive compulsive disorder consecutively referred to a centre specialising in the behavioural treatment of anxiety disorders. Females had a later mean onset-age, and were more likely to be married and to have children; they were also marginally more likely to have a past history of an eating disorder or depression, while males were more likely to have a history of anxious or meticulous personality traits. Family loading for psychiatric disorders did not differ significantly between the sexes. The results are discussed in the context of the epidemiological literature on gender differences in OCD.

scholarly journals Obsessive-Compulsive Disorder with Suicide Obsessions in a First Responder without Previous Diagnosis of OCD or History of Suicide Attempts

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Vivekananda Rachamallu ◽  
Michael M. Song ◽  
Haiying Liu ◽  
Charles L. Giles ◽  
Terry McMahon
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Suicide Attempts ◽  
Past History ◽  
Case Reports ◽  
First Responder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Prevention Therapy ◽  
Increased Risk ◽  
History Of

Obsessive-compulsive disorder (OCD) is a distressing and often debilitating disorder characterized by obsessions, compulsions, or both that are time-consuming and cause impairment in social, occupational, or other areas of functioning. There are many published studies reporting higher risk of suicidality in OCD patients, as well as studies describing increased risk of suicidality in OCD patients with other comorbid psychiatric conditions such as major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Existing case reports on OCD with suicide as the obsessive component describe patients with long standing diagnosis of OCD with suicidal ideations or previous suicide attempts. This report describes the case of a 28-year-old male, who works as a first responder, who presented with new onset symptoms characteristic of MDD and PTSD, with no past history of OCD or suicidality who developed OCD with suicidal obsessions. Differentiating between suicidal ideation in the context of other psychiatric illnesses and suicidal obsessions in OCD is critical to ensuring accurate diagnosis and timely provision of most appropriate treatment. The combination of exposure and response prevention therapy and pharmacotherapy with sertraline and olanzapine was effective in helping the patient manage the anxiety and distress stemming from the patient’s OCD with suicidal obsession.

Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder

2019 ◽  
Vol 271 ◽  
pp. 554-558 ◽  
Author(s):  
Maria Teresa Plana ◽  
Teresa Torres ◽  
Natalia Rodríguez ◽  
Daniel Boloc ◽  
Patricia Gassó ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Genetic Variability ◽  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Serotoninergic System ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Predicting Eating Disorder and Anxiety Symptoms Using Anorexia Nervosa and Obsessive-Compulsive Disorder Polygenic Scores

2020 ◽  
Author(s):  
Zeynep Yilmaz ◽  
Katherine Schaumberg ◽  
Matt Halvorsen ◽  
Erica L. Goodman ◽  
Leigh C. Brosof ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Sex Differences ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Obsessive Compulsive Disorder ◽  
Genetic Risk ◽  
Anxiety Symptoms ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Polygenic Scores

Clinical, epidemiological, and genetic findings support an overlap between eating disorders, obsessive-compulsive disorder (OCD), and anxiety symptoms. However, little research has examined the role of genetic factors in the expression of eating disorders and OCD/anxiety phenotypes. We examined whether the anorexia nervosa (AN), OCD, or AN/OCD transdiagnostic polygenic scores (PGS) predict eating disorders, OCD, and anxiety symptoms in a large population-based developmental cohort. Using summary statistics files from the Psychiatric Genomics Consortium Freeze 2 AN and Freeze 1 OCD GWAS, we first conducted an AN/OCD transdiagnostic GWAS meta-analysis and then calculated PGS for AN, OCD, and AN/OCD in participants from the Avon Longitudinal Study of Parents and Children with available genetic and phenotype data on eating disorder, OCD, and anxiety diagnoses and symptoms (sample size 3,212-5,369 per phenotype). We observed sex differences in the PGS prediction of eating disorder, OCD, and anxiety-related phenotypes, with AN genetic risk manifesting at an earlier age and playing a more prominent role in eating disorder phenotypes in boys than in girls. Compulsive exercise was the only phenotype predicted by all three PGS (e.g., PAN(boys)=0.0141 at age 14; POCD(girls)=0.0070 at age 16; PAN/OCD(all)=0.0297 at age 14). Our results suggest that earlier detection of eating disorder, OCD, and anxiety-related symptoms could be made possible by including measurement of genetic risk for these psychiatric conditions while being mindful of sex differences.

PROLACTIN IN CHILDHOOD OBSESSIVE-COMPULSIVE DISORDER: CLINICAL CORRELATES AND RESPONSE TO CLOMIPRAMINE

PEDIATRICS ◽  
1991 ◽  
Vol 88 (5) ◽  
pp. 992-992
Author(s):  
Gregory L. Hanna ◽  
James T. MCCracken ◽  
Dennis P. Cantwell
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Serotonergic Receptors ◽  
Duration Of Illness ◽  
Chronic Tic Disorder ◽  
History Of ◽  
Clomipramine Treatment

Basal prolactin concentrations were measured before treatment in 18 children and adolescents with obsessive-compulsive disorder as well as in 15 of these patients after 4 and 8 weeks of clomipramine treatment. Basal prolactin levels were influenced by a history of chronic tic disorder and by the duration and severity of obsessive-compulsive symptoms. Clomipramine administration significantly increased basal prolactin levels. A slight decline in prolactin levels during the last 4 weeks of clomipramine treatment was positively correlated with a favorable treatment response and negatively correlated with duration of illness. If the changes in prolactin levels observed during clomipramine treatment are due primarily to changes in serotonergic neurotransmission, these data suggest that clomipramine treatment of obsessive-compulsive disorder produces an adaptive decrease in the responsiveness of serotonergic receptors.

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